Pharmacokinetics

Pharmacokinetics (Greek: Kinesis-movement) is What the body does to the drug.
It refers to the movements of the drug in and alteration of the drug by the body; includes absorption, distribution, binding/ localization/ storage, biotransformation and excretion of the drug, eg. Digoxin is ~70% absorbed orally; 25% bound to plasma proteins; localized in heart, skeletal muscle, liver and kidney; widely distributed (volume of distribution ~6L/kg); a small fraction is metabolized in liver to inactive products and is primarily excreted unchanged by glomerular filtration in kidney, has a total body clearance of ~150mL/min and a plasma half life (t1/2) of ~40 hours.